microcrystalline cellulose msds fmc

Trademarks: Avicel PH-102. CAS 9004-34-6. SUBSTANCE IDENTIFICATION 1.1. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Revision No. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. The most. Validity Area. A., and Smith, P. A. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. 4 0 obj You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Chemical Formula: (C6H10O5)n 1.4. Looking for FMC'searnings news? Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . 2021 Annual Report. Micro Crystalline Cellulose. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe 9,LL!z The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Revision No. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Avicel Microcrystalline Cellulose Physical Properties. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER MATERIAL SAFETY DATA SHEET. We are artists at heart and creators by nature. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Manufactured by: China . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Request media, explore upcoming events and read our latest updates. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. CoA. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Microcrystalline Cellulose / Avicel PH-102. Microcrystalline Cellulose (MCC) Manufacturing Industry. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. MATERIAL SAFETY DATA SHEET Version: 1.0 1. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. <> No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . 51395-75-6 Avicel RC 591. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. . Buy Chemicals. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. The typical mean particle size is 20200 m. % This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Molecular weight: Not Applicable 1.5. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 4. These, in turn, are assembled into fibrils in the cell wall. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. It is also inert and biocompatible. stream Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. (Microcrystalline Cellulose Market Pr. Wu, K. Zuurman, H.W. 1 0 obj cas:9000-11-7 msds Carboxymethyl cellulose. Created Date: 2/10/2020 8:51:41 PM . 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. ). Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is also used in plaque assays for counting. Your file is uploaded and ready to be published. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Avicel PC 611 (FMC Biopolymer) . Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. 2008-2023 ChemPoint. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. [FMC Study Number I92-1464]. endobj METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Product Name: Microcrystalline Cellulose 1.2. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Avicel PH-101. common form is used in vitamin supplements or tablets. INCI. 130. Battista, O. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . 0.25 - 0.37. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . These grades have particle sizes ranging from <30 to approximately 200. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Truly distinctive drug delivery solutions. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Instead, they obtained a stable colloidal suspension. No. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? . EMCOCEL 90 M. 130. << Watch Now. Have an order or account question? Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. B;vLZpHU%ChUyD+[ It is . SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Material safety data sheet - FMC Corporation. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. JFIF ` ` ZExif MM * J Q Q Q C All rights reserved. Meet our leadership team. . From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. }o]X4]. endobj AVICEL RC 581. Unique functionality for a broad range of pharmaceutical applications. Apply today! Safety Data Sheet (SDS) Viewer. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. SUBSTANCE IDENTIFICATION 1.1. Well-recognized product that can do it all. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Cellulose microcrystalline. q86@on$^X_HuH;3` SCMm_>x^O9l (n. Product Name: Microcrystalline Cellulose E460 1.2. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. 8 0 obj FMC, JRS and Mingtai were estimated to hold for . In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. : CL-611NF Date Approved: 01/13/2010. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. . *r_ *?~4$ &0Y# 4 0 obj <> PDF (28.38 mb) 2022 Corporate Fact Sheet. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. <> Protect them from sunshine or rain. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Report Category. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. BIOACCUMULATIVE POTENTIAL : 9004-34-6 Date Approved: 01/31/2008 . FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Page 1 of 8. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. In large quantities it provides dietary bulk and may lead to a laxative effect. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. In extrusion-spheronisation, it is the excipient of choice. Microcrystalline Cellulose Side Effects. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Synonyms: Cellulose, Cellulose powder, Cotton linters. ( Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Origin(s): Plant/Botanical. Learn about FMC's industry leading goal of net-zero emissions by 2035. The data shown below apply only to Avicel PH 101. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. 0.25 - 0.37. Molecular weight: Not Applicable 1.5. Terms and Conditions Compliance Solutions Industries About 3E News & Events . No. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. However, if handling bulk powders, observance of appropriate safeguards is recommended. We know that our customers need to provide reliable and consistent products to their patients. Explore how we work and why we apply science and creativity for a better world to everything we do. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance.

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